Article

Engraftment and injury repair in regionally conditioned rat lung <i>in vivo</i> by lung progenitors derived from human pluripotent stem cells

2023-11-29

Abstract excerpt

Although lung disease is a major cause of mortality, the mechanisms involved in human lung regeneration are unclear because of the lack of experimental models. Here we report a novel model where human pluripotent stem cell-derived expandable cell lines sharing features of airway secretory and basal cells engraft in the distal rat lung after conditioning by locoregional de-epithelialization followed by irradiation...

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Literature Corpus work: e9f02240-1165-544a-bf88-ac9c64e03321
DOI: 10.1101/2023.11.28.569060

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