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Airway stem cell reconstitution by the transplantation of primary or pluripotent stem cell-derived basal cells

24 Aug 2023

Abstract excerpt

Life-long reconstitution of a tissue's resident stem cell compartment with engrafted cells has the potential to durably replenish organ function. Here, we demonstrate the engraftment of the airway epithelial stem cell compartment via intra-airway transplantation of mouse or human primary and pluripotent stem cell (PSC)-derived airway basal cells (BCs). Murine primary or PSC-derived BCs transplanted into...

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PMID: 37625411
DOI: 10.1016/j.stem.2023.07.014

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