Article

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank

2021-12-16

Abstract excerpt

<h4>Background</h4> The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring CNVs in large enough sample sizes to detect associations. The recent availability of whole-exome sequencing (WES) in large biobank studies provides an unprecedented opportunity to study the role of CNVs in asthma. <h4>Methods</h4> We called...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9ee1708-9e15-5e76-bc26-bbf0a250e821
DOI: 10.1101/2021.12.15.21267845

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK BiobankDOI 10.1101/2021.12.15.21267845Read

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank.Semantic proximity Read

Copy number variation prevalence in known asthma genes and their impact on asthma susceptibility.Semantic proximity Read

Copy Number Variation in Asthma: An Integrative Review.Semantic proximity Read

A phenome-wide association study of CNVs genotyped from genome sequencing read depth in the UK Biobank.Semantic proximity Read

Lessons from ten years of genome‐wide association studies of asthmaSemantic proximity Read

Next Generation Exome Sequencing of paediatric Asthma Identifies Rare and Novel Variants in Candidate GenesSemantic proximity Read

A phenome-wide association study of CNVs genotyped from genome sequencing read depth in the UK BiobankSemantic proximity Read

Exon variants associated with asthma and allergy<sup>1</sup>Semantic proximity Read

Whole-genome sequencing of individuals from a founder population identifies candidate genes for asthma.Semantic proximity Read

Exome variants associated with asthma and allergy.Semantic proximity Read

Identification of deleterious and regulatory genomic variations in known asthma lociSemantic proximity Read

Analysis of rare coding variants in 470,000 UK Biobank participants reveals genetic associations with childhood asthma predispositionSemantic proximity Read