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Article

Exome-wide analysis of copy number variation shows association of the human leukocyte antigen region with asthma in UK Biobank.

BMC medical genomics - 21 May 2022

Fawcett Katherine A, Demidov German, Shrine Nick, Paynton Megan L, Ossowski Stephan, Sayers Ian, Wain Louise V, Hollox Edward J

Abstract excerpt

BACKGROUND: The role of copy number variants (CNVs) in susceptibility to asthma is not well understood. This is, in part, due to the difficulty of accurately measuring CNVs in large enough sample sizes to detect associations. The recent availability of whole-exome sequencing (WES) in large biobank studies provides an unprecedented opportunity to study the role of CNVs in asthma. METHODS: We called common CNVs in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35597955
DOI: 10.1186/s12920-022-01268-y
PMCID: PMC9124406

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