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Generation of a transgenic P <i>. cynomolgi</i> parasite expressing <i>P. vivax</i> circumsporozoite protein for testing pre-erythrocytic malaria vaccines in non-human primates

2024-12-26

Abstract excerpt

Malaria, caused by infection with Plasmodium parasites, exacts a heavy toll worldwide. There are two licensed vaccines for malaria as well as two monoclonal antibodies that have shown promising efficacy in field trials. Both vaccines and monoclonals target the major surface protein (circumsporozoite protein, CSP) of Plasmodium falciparum . Yet Pf is only one of the four major species of Plasmodium that infects...

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Literature Corpus work
e9a8bb62-ad35-5163-a2b2-ee94353a33bd
DOI
10.1101/2024.12.26.630255
Open publication

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Generation of a transgenic P <i>. cynomolgi</i> parasite expressing <i>P. vivax</i> circumsporozoite protein for testing pre-erythrocytic malaria vaccines in non-human primatesDOI 10.1101/2024.12.26.630255
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