Article

Transfection Models to Investigate Plasmodium vivax-Type Dormant Liver Stage Parasites

2023-07-20

Abstract excerpt

Plasmodium vivax causes the second highest number of malaria morbidity and mortality cases in humans. Several biological traits of this parasite species, including the formation of dormant stages (hypnozoites) that persist inside the liver for prolonged periods of time, present an obstacle for intervention measures and create a barrier for the elimination of malaria. Research into the biology of hypnozoites requir...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e86ad933-98fb-52dd-a369-20e76986beeb
DOI: 10.20944/preprints202307.1346.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transfection Models to Investigate Plasmodium vivax-Type Dormant Liver Stage ParasitesDOI 10.20944/preprints202307.1346.v1Read

Transgenic Fluorescent Plasmodium cynomolgi Liver Stages Enable Live Imaging and Purification of Malaria Hypnozoite-FormsSemantic proximity Read

A dual fluorescent Plasmodium cynomolgi reporter line reveals in vitro malaria hypnozoite reactivationSemantic proximity Read

Culture and transfection: Two major bottlenecks in understanding Plasmodium vivax biologySemantic proximity Read

In Vitro Culture, Drug Sensitivity, and Transcriptome of Plasmodium Vivax HypnozoitesSemantic proximity Read

Hepatic spheroids used as an in vitro model to study malaria relapseSemantic proximity Read

Transfection of the human malaria parasite Plasmodium falciparum.Semantic proximity Read

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stagesSemantic proximity Read

Liver stage fate determination in <i>Plasmodium vivax</i> parasites: characterization of schizont growth and hypnozoite fating from patient isolatesSemantic proximity Read

Plasmodium vivax Liver Stage Development and Hypnozoite Persistence in Human Liver-Chimeric MiceSemantic proximity Read

A single-cell liver atlas of Plasmodium vivax infectionSemantic proximity Read

A Research Agenda for Malaria Eradication: Basic Science and Enabling TechnologiesSemantic proximity Read

Generation of a transgenic P <i>. cynomolgi</i> parasite expressing <i>P. vivax</i> circumsporozoite protein for testing pre-erythrocytic malaria vaccines in non-human primatesSemantic proximity Read