Article

LRH-1 NUTRIGENOMICS: The Provision of Lauric Acid Results in the Endogenous Production of the Liver Receptor Homolog-1 Ligand, Dilauroylphosphatidylcholine, and LRH-1 Transactivation

2021-02-02

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> The unusual phosphatidylcholine species, dilauroylphosphatidylcholine (DLPC), has been reported to bind and activate the orphan nuclear receptor, liver receptor homolog-1 (LRH-1). To date, DLPC has not been reported endogenously in metabolomic databases. <h4>Objective</h4> Herein, we test the hypothesis that the provision of the acyl constituent of DLPC, lauric acid (C12:0)...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e9882142-8e89-56cb-8b5f-0034873eac2b
DOI: 10.1101/2021.02.01.429240

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

LRH-1 NUTRIGENOMICS: The Provision of Lauric Acid Results in the Endogenous Production of the Liver Receptor Homolog-1 Ligand, Dilauroylphosphatidylcholine, and LRH-1 TransactivationDOI 10.1101/2021.02.01.429240Read

Liver lipid droplet cholesterol content is a key determinant of metabolic dysfunction-associated steatohepatitisSemantic proximity Read

Dyslipidemic SPTLC3 Integrates Bile Acid-FXR Signaling with Sphingolipid Remodeling in MASLDSemantic proximity Read

LRH-1 Ameliorates Hepatic Triglyceride Accumulation via Regulation of Perilipin 5 in the LiverSemantic proximity Read

Physiology and pathophysiology of sphingolipid metabolism and signalingSemantic proximity Read

Integrated gut–liver-on-a-chip platform as an <i>in vitro</i> human model of non-alcoholic fatty liver diseaseSemantic proximity Read

A Facile LC-MS Method for Profiling Cholesterol and Cholesteryl Esters in Mammalian Cells and TissuesSemantic proximity Read

The role of lecithin:cholesterol acyltransferase in the modulation of cardiometabolic risks — A clinical update and emerging insights from animal modelsSemantic proximity Read

Dietary fat enhanced chylomicron-mediated LPS translocation in a Caco-2 transwell modelSemantic proximity Read

Liver-specific expression of transcriptionally active SREBP-1c is associated with fatty liver and increased visceral fat mass.Semantic proximity Read

Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper DeficiencySemantic proximity Read

Offspring NAFLD liver phospholipid profiles are differentially programmed by maternal high-fat diet and maternal one carbon supplementSemantic proximity Read

Choline: clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements.Semantic proximity Read