Article

NAMPT-derived NAD <sup>+</sup> fuels PARP1 to promote skin inflammation through parthanatos

2021-02-22

Abstract excerpt

<h4>Summary</h4> Several studies have revealed a correlation between chronic inflammation and NAD + metabolism but the precise mechanism involved is unknown. Here we report that the genetic and pharmacological inhibition of nicotinamide phosphoribosyltransferase (Nampt), the rate-limiting enzyme in the salvage pathway of NAD + biosynthesis, reduced oxidative stress, inflammation, and keratinocyte DNA damage, hy...

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Identifiers and source

Literature Corpus work: e9307281-2163-5299-bba6-735e54261991
DOI: 10.1101/2021.02.19.431942

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