Article

SPECC1L-deficient palate mesenchyme cells show speed and directionality defect

2019-11-25

Abstract excerpt

Clefts of the lip and/or palate (CL/P) are common anomalies that occur in 1/800 live births. Pathogenic SPECC1L variants identified in patients with rare atypical clefts and syndromic CL/P suggest the gene plays a primary role in face and palate development. We have generated Specc1l gene-trap ( Specc1l cGT ) and truncation ( Specc1l ΔC510 ) alleles that cause embryonic or perinatal lethality, respectively....

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Literature Corpus work: e8efdd29-f23f-59aa-85aa-77192278cca2
DOI: 10.1101/854273

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