Article

The Hidden Disorder Divide: Reconciling Benchmark Inconsistencies in Intrinsically Disordered Protein Binding Site Prediction

2026-06-27

Abstract excerpt

Computational predictors of protein-binding sites within intrinsically disordered regions (IDRs) show highly inconsistent performance across high-quality benchmark datasets. To understand the origins of these discrepancies, we systematically compared predictors across three independent test sets: two CAID datasets updated with the latest DisProt annotations and a composite dataset (DBs) assembled from DIBS, FuzDB,...

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Literature Corpus work: e8c6cfef-9b1d-5439-8deb-dc85dea257d1
DOI: 10.64898/2026.06.24.733783

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