Article

Directional and balancing selection on proprotein convertase subtilisin/kexin type 6 (PCSK6)

2016-06-18

Abstract excerpt

The selective pressures challenging the human population leave genetic signatures. This study was designed to detect positive and balancing selection on the proprotein convertase subtilisin/kexin type 6 (PCSK6) gene by four different approaches (FDIST, BayeScan, EHH, iHS). The outlier programs FDIST and BayeScan found 27 overlapping single nucleotide polymorphisms (SNPs) under selection, of which twelve are under...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e877a264-97ad-5ebc-b245-97240c22a715
DOI: 10.7287/peerj.preprints.2141v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest

Directional and balancing selection on proprotein convertase subtilisin/kexin type 6 (PCSK6)DOI 10.7287/peerj.preprints.2141v1Read

Evidence for positive selection in the C-terminal domain of the cholesterol metabolism gene PCSK9 based on phylogenetic analysis in 14 primate species.Semantic proximity Read

Molecular population genetics of PCSK9: a signature of recent positive selection.Semantic proximity Read

The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts.Semantic proximity Read

Positive selection in the chromosome 16 VKORC1 genomic region has contributed to the variability of anticoagulant response in humans.Semantic proximity Read

PCSK6 VNTR Polymorphism Is Associated with Degree of Handedness but Not Direction of Handedness.Semantic proximity Read

Single-nucleotide polymorphisms of the proprotein convertase subtilisin/ kexin type 5 (PCSK5) gene.Semantic proximity Read

Local selection of human populations shapes complex evolution patterns of CXCL10 gene.Semantic proximity Read

Signatures of long-term balancing selection in human genomesSemantic proximity Read