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Article

Positive selection in the chromosome 16 VKORC1 genomic region has contributed to the variability of anticoagulant response in humans.

PloS one - 1 Jan 2012

Patillon Blandine, Luisi Pierre, Blanché Hélène, Patin Etienne, Cann Howard M, Génin Emmanuelle, Sabbagh Audrey

Abstract excerpt

VKORC1 (vitamin K epoxide reductase complex subunit 1, 16p11.2) is the main genetic determinant of human response to oral anticoagulants of antivitamin K type (AVK). This gene was recently suggested to be a putative target of positive selection in East Asian populations. In this study, we genotyp...

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Share to Chromosomes, Human, Pair 16

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23285254
DOI: 10.1371/journal.pone.0053049
PMCID: PMC3532425

Genes

VKORC1
BCKDK
KAT8
PRSS8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23285254-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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