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Article

The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts.

Human molecular genetics - 1 May 2016

Shore Robert, Covill Laura, Pettigrew Kerry A, Brandler William M, Diaz Rebeca, Xu Yiwang, Tello Javier A, Talcott Joel B, Newbury Dianne F, Stein John, Monaco Anthony P, Paracchini Silvia

Abstract excerpt

We recently reported the association of the PCSK6 gene with handedness through a quantitative genome-wide association study (GWAS; P < 0.5 × 10(-8)) for a relative hand skill measure in individuals with dyslexia. PCSK6 activates Nodal, a morphogen involved in regulating left-right body axis determination. Therefore, the GWAS data suggest that the biology underlying the patterning of structural asymmetries may...

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Identifiers

PMID: 26908617
DOI: 10.1093/hmg/ddw047
PMCID: PMC4986331

Genes

PCSK6

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