Back to search

Article

TNFRSF12A Drives Triple-Negative Breast Cancer Progression via Immune Microenvironment Reprogramming and Facilitated Angiogenesis

2025-08-29

Abstract excerpt

The urgent need for novel therapeutic strategies in triple-negative breast cancer (TNBC)—characterized by absent ER, PR, and HER2 expression—stems from its association with a paucity of effective treatments and an adverse prognosis. This study identifies TNFRSF12A as a key gene specifically overexpressed in TNBC versus other subtypes. Validation with clinical specimens confirmed its exclusive upregulation in TNBC...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
e7ffdcd5-b6d4-51d0-a237-4c5e04f59524
DOI
10.20944/preprints202508.2183.v1
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
TNFRSF12A Drives Triple-Negative Breast Cancer Progression via Immune Microenvironment Reprogramming and Facilitated AngiogenesisDOI 10.20944/preprints202508.2183.v1
Interleukin-17-based cytokine signaling as a determinant for tumor immune microenvironment with prognostic value in triple-negative breast cancerSemantic proximity
Inflammation-associated drug resistance and tumor growth in TNBCSemantic proximity
Multi-omics analyses of the heterogenous immune microenvironment in triple-negative breast cancer implicate UQCRFS1 potentiates tumor progressionSemantic proximity
Immune Microenvironment-Related Genes Contribute to Clinical Prognosis in Patients with Triple-Negative Breast CancerSemantic proximity
Unraveling Triple-Negative Breast Cancer Tumor Microenvironment Heterogeneity: Towards an Optimized Treatment ApproachSemantic proximity
The IL-8/NF-κB feedback loop confers a paclitaxel-sensitive/doxorubicin-resistant phenotype in triple-negative breast cancerSemantic proximity
Thirteen tumor necrosis factor receptor superfamily gene expression in malignancies and their clinical relevance to immunotherapy: a pan-cancer analysisSemantic proximity
A novel model associated with tumor microenvironment on predicting prognosis and immunotherapy in Triple Negative Breast CancerSemantic proximity
Molecular subtyping and functional validation of TTK, TPX2, UBE2C, and LRP8 in sensitivity of TNBC to paclitaxelSemantic proximity
TNFRSF12A is associated with immune cell infiltration in thyroid carcinomaSemantic proximity
A CTL/M2 Macrophage-Related Four-Gene Signature Predicting Metastasis-Free Survival in Triple-Negative Breast Cancer Treated with Adjuvant RadiotherapySemantic proximity
Comprehensive Analysis of the Immune Microenvironment Reveals that CD52 is a Marker for Breast Cancer Treatment with Immune Checkpoint InhibitorsSemantic proximity
Select a neighboring publication to make it the new centre.