Article

Molecular Dynamics simulation of NRAS-Q61 oncogenes and new strategies for <i>in silico</i> drug design

2023-05-26

Abstract excerpt

The NRAS-mutant subset of melanoma represents the most aggressive and the deadliest types associated with poorer overall survival. Unfortunately, for more than 40 years, no therapeutic agent directly targeting NRAS mutations have been clinically approved yet. Herein, based on microsecond scale molecular dynamics simulations, the concept of NRAS-Q61 mutation classification was firstly proposed. NRAS Q61 positively...

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Literature Corpus work: e7e989c7-6289-5566-a524-dc18dfabc1ca
DOI: 10.1101/2023.05.25.542304

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