Article

Quantitative comparison of the structural differences between NRAS and its mutations by well-tempered metadynamics simulations

2024-08-10

Abstract excerpt

The NRAS-mutant subset of melanoma is one of the most aggressive and lethal types associated with poor overall survival. Unfortunately, a low understanding of the NRAS-mutant dynamic behavior has lead to the lack of clinically approved therapeutic agents able to directly target NRAS oncogenes. In this work, accurate local structures of NRAS and its mutants have been fully explored through the corresponding free en...

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Literature Corpus work: b5074bd4-7080-5c09-9a9c-ea8d31c21c91
DOI: 10.1101/2024.08.09.607354

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