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Article

Powerful extreme phenotype sampling designs and score tests for genetic association studies.

Statistics in medicine - 10 Dec 2018

Bjørnland Thea, Bye Anja, Ryeng Einar, Wisløff Ulrik, Langaas Mette

Abstract excerpt

We consider cross-sectional genetic association studies (common and rare variants) where non-genetic information is available or feasible to obtain for N individuals, but where it is infeasible to genotype all N individuals. We consider continuously measurable Gaussian traits (phenotypes). Genotyping n < N extreme phenotype individuals can yield better power to detect phenotype-genotype associations, as compared...

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PMID: 30088284
DOI: 10.1002/sim.7914

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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