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Integrative bulk and single-cell transcriptomics identify a chemoresistance-related risk model for recurrence prediction in colorectal cancer

2026-02-17

Abstract excerpt

<title>Abstract</title> <p>Chemoresistance remains a major obstacle to improving outcomes in colorectal cancer (CRC), particularly among patients receiving 5-fluorouracil (5-FU)–based therapy. Here, we developed and validated a drug resistance–related gene signature to predict recurrence and treatment response in CRC. In the GSE190826 cohort, patients without pathological complete response (non-pCR) exhibited sig...

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Literature Corpus work
e74e9da6-af86-59e6-9867-b0b459da75dc
DOI
10.21203/rs.3.rs-8797652/v1
Open publication

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Integrative bulk and single-cell transcriptomics identify a chemoresistance-related risk model for recurrence prediction in colorectal cancerDOI 10.21203/rs.3.rs-8797652/v1
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