Article

Pharmacometric assessment of primaquine induced haemolysis in glucose-6-phosphate dehydrogenase deficiency

2023-02-25

Abstract excerpt

<h4>Background</h4> Primaquine is an 8-aminoquinoline antimalarial. It is the only widely available treatment to prevent relapses of Plasmodium vivax malaria. The 8-aminoquinolines cause dose dependent haemolysis in glucose-6-phosphate dehydrogenase deficient (G6PDd) individuals. G6PDd is common in malaria endemic areas but testing is often not available. As a consequence primaquine is underused. <h4>Methods</h...

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Literature Corpus work: e6f47d7a-f61a-5eff-ab34-6ea9b27832f7
DOI: 10.1101/2023.02.24.23286398

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