Article

Predicting Disease-Specific Histone Modifications and Functional Effects of Non-coding Variants by Leveraging DNA Language Models

2025-06-17

Abstract excerpt

<h4>Background: </h4> Epigenetic modifications play a vital role in the pathogenesis of human diseases, particularly neurodegenerative disorders such as Alzheimer's disease (AD), where dysregulated histone modifications are strongly implicated in disease mechanisms. While recent advances underscore the importance of accurately identifying these modifications to elucidate their contribution to AD pathology, existin...

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Literature Corpus work: e6b4b972-d315-5285-aa26-e346147ac410
DOI: 10.1101/2025.06.15.659749

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