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Class switching toward IgG4 six months after primary mRNA-based COVID-19 vaccination in kidney patients

2025-10-28

Abstract excerpt

<h4>Background</h4> Class switching toward spike (S)-binding IgG4 antibodies after mRNA-based COVID-19 vaccination has been observed, an antibody subclass with strong neutralizing but limited effector activity. While this has been reported in healthy individuals, subclass dynamics in immunocompromised kidney patients are unclear. We assessed IgG subclass patterns and S-specific B-cell phenotypes up to 6 months af...

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Literature Corpus work
b5471ab2-0ca0-50be-a879-c9456347abce
DOI
10.1101/2025.10.26.25338845
Open publication

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Class switching toward IgG4 six months after primary mRNA-based COVID-19 vaccination in kidney patientsDOI 10.1101/2025.10.26.25338845
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