Article

Evolution of SIV toward RANTES resistance in macaques rapidly progressing to AIDS upon coinfection with HHV-6A

2009-07-02

Abstract excerpt

Abstract Background Progression to AIDS is often associated with the evolution of HIV-1 toward increased virulence and/or pathogenicity. Evidence suggests that a virulence factor for HIV-1 is resistance to CCR5-binding chemokines, most notably RANTES, which are believed to play a role in HIV-1 controlin vivo. HIV-1 can achieve RANTES resistance either by phenotypic switching from an exclusive CCR5 usage to an expa...

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Identifiers and source

Literature Corpus work: e6767598-6076-52f9-bfce-708133764e05
DOI: 10.1186/1742-4690-6-61

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