Article

The carboxy-terminal ER-retention motif, SEKDEL, influences the N-linked glycosylation of recombinant human α-l-iduronidase but has little effect on enzyme activity in seeds of Brassica napus and Nicotiana tabacum

2010-05-01

Abstract excerpt

One of the potential drawbacks of the use of plant-based systems for production of human glycoproteins is the presence of immunogenic sugars within the protein's glycans, especially xylose. This can occur as a consequence of the protein undergoing transit through the plant Golgi complex, in which modifying enzymes may convert the high-mannose N-glycans of the recombinant protein to complex forms. In an effort to m...

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Literature Corpus work: e676009a-1c65-5187-bae7-d44ce318dfa9
DOI: 10.1016/j.plantsci.2010.02.004

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The carboxy-terminal ER-retention motif, SEKDEL, influences the N-linked glycosylation of recombinant human α-l-iduronidase but has little effect on enzyme activity in seeds of Brassica napus and Nicotiana tabacumDOI 10.1016/j.plantsci.2010.02.004Read

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