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Article

Carbapenemase-loaded outer membrane vesicles protect Pseudomonas aeruginosa by degrading imipenem and promoting mutation of antimicrobial resistance gene.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 May 2023

Zhang Xiaotuan, Qian Changrui, Tang Miran, Zeng Weiliang, Kong Jingchun, Fu Cheng, Xu Chunquan, Ye Jianzhong, Zhou Tieli

Abstract excerpt

AIMS: To investigate the effect of Klebsiella pneumoniae carbapenemase (KPC)-loaded outer membrane vesicles (OMVs) in protecting Pseudomonas aeruginosa against imipenem treatment and its mechanism. METHODS: The OMVs of carbapenem-resistant Klebsiella pneumonia (CRKP) were isolated and purified from the supernatant of bacterial culture by using ultracentrifugation and Optiprep density gradient ultracentrifugation....

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Identifiers

PMID: 36812748
DOI: 10.1016/j.drup.2023.100952

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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