Article

Constitutively active RAS in <i>S. pombe</i> causes persistent Cdc42 signalling but only transient MAPK activation

2018-07-30

Abstract excerpt

The small GTPase RAS is a signalling hub for many pathways and oncogenic human RAS mutations are assumed to over-activate all of its downstream pathways. We tested this assumption in fission yeast, where, RAS-mediated pheromone signalling (PS) activates the MAPKSpk1 and Cdc42 pathways. Unexpectedly, we found that constitutively active Ras1.G17V induced immediate but only transient MAPKSpk1 activation, whilst Cdc42...

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Literature Corpus work: e60d7d6d-017a-5d01-8f02-f02672da9a51
DOI: 10.1101/380220

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