Article

Vicious cycle of hemodynamic perturbation and endothelial injury in development and progression of pulmonary arterial hypertension

2023-10-19

Abstract excerpt

<h4>Background</h4> Pulmonary arterial hypertension (PAH) is a devastating disease caused by loss of effective lung microvasculature for which there is no curative treatment. Evidence from preclinical models and human disease-causing genetic mutations point to endothelial cell (EC) injury and apoptosis as a central trigger for the initiation of PAH. However, how EC apoptosis leads to pulmonary hypertension (PH) a...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5f1458b-8fd8-5f98-87ce-d163839393e1
DOI: 10.1101/2023.10.16.562339

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Vicious cycle of hemodynamic perturbation and endothelial injury in development and progression of pulmonary arterial hypertensionDOI 10.1101/2023.10.16.562339Read

Emergence of disease-specific endothelial and stromal cell populations responsible for arterial remodeling during development of pulmonary arterial hypertensionSemantic proximity Read

Role of apoptosis in pulmonary hypertension: from experimental models to clinical trials.Semantic proximity Read

Reconciling paradigms of abnormal pulmonary blood flow and quasi-malignant cellular alterations in pulmonary arterial hypertension.Semantic proximity Read

[Pulmonary hypertension: from molecular pathophysiology to haemodynamic abnormalities].Semantic proximity Read

Janus face of vascular endothelial growth factor: the obligatory survival factor for lung vascular endothelium controls precapillary artery remodeling in severe pulmonary hypertension.Semantic proximity Read

Clonally selected primitive endothelial cells promote occlusive pulmonary arteriopathy and severe pulmonary hypertension in rats exposed to chronic hypoxiaSemantic proximity Read

Mapping disease-specific vascular cell populations responsible for obliterative arterial remodelling during the development of pulmonary arterial hypertension.Semantic proximity Read

Endothelial dysfunction in pulmonary arterial hypertension: an evolving landscape (2017 Grover Conference Series)Semantic proximity Read

Pathogenic mechanisms of pulmonary arterial hypertension.Semantic proximity Read

The pathobiology of pulmonary hypertension. Endothelium.Semantic proximity Read

Hypoxia-induced pulmonary vascular remodeling: cellular and molecular mechanisms.Semantic proximity Read

General Capillary Endothelial Cells Undergo Reprogramming into Arterial Endothelial Cells in Pulmonary Hypertension through HIF-2α/Notch4 PathwaySemantic proximity Read