Article

High throughput screening identifies broad-spectrum Coronavirus entry inhibitors

2023-12-05

Abstract excerpt

The Covid-19 pandemic highlighted the pressing need for antiviral therapeutics capable of mitigating infection and spread of emerging coronaviruses (CoVs). A promising therapeutic strategy lies in inhibiting viral entry mediated by the Spike (S) glycoprotein. To identify small molecule inhibitors that block entry downstream of receptor binding, we established a high-throughput screening (HTS) platform based on pse...

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Literature Corpus work: 18b1a281-0f76-5588-b696-c495ef745dc6
DOI: 10.1101/2023.12.04.569985

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