Article

Loss of <i>ATG5</i> expression in a subset of human prostate cancers promotes tumor growth through accumulation of p62

2025-05-08

Abstract excerpt

<h4>ABSTRACT</h4> Loss-of-function mutations in autophagy-related (ATG) genes are rare in cancer. However, we report herein that ATG5 is fully deleted in ∼14% of prostate cancers (PCa), rivaling that of well-established tumor suppressor genes. ATG5 expression was downregulated at both mRNA and protein levels and was associated with poor patient survival. The DU145 PCa cell line, isolated from a brain metastasis,...

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Literature Corpus work: e5e0ffa7-a4d2-542d-95ae-17b6fb88f718
DOI: 10.1101/2025.05.02.651776

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