Article

SphK-produced S1P in somatic cells is indispensable for LH-EGFR signaling-induced mouse oocyte maturation

2022-07-29

Abstract excerpt

<title>Abstract</title> <p>Germ cells division and differentiation requires intimate contact and interaction with the surrounding somatic cells. Luteinizing hormone (LH) triggers epidermal growth factor (EGF)-like growth factors to promote oocyte maturation and developmental competence by activating EGF receptor (EGFR) in somatic cells. Here, we show that LH-EGFR signaling activates sphingosine kinases (SphK1 and...

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Literature Corpus work: e5c35687-8db9-5e39-9350-b4b981e9c909
DOI: 10.21203/rs.3.rs-1727460/v1

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