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Article

Significance of epidermal growth factor receptor signaling for acquisition of meiotic and developmental competence in mammalian oocytes†

31 Aug 2017

Abstract excerpt

The surge in luteinizing hormone (LH) in preovulatory ovarian follicles triggers the resumption of oocyte meiosis accompanied by expansion of surrounding cumulus cells and ovulation of cumulus-oocyte complexes (COCs) into the oviduct. Over the last 15 years, substantial progress has been made in elucidating the key pathways by which the LH signal spreads within the preovulatory follicle and in identifying the...

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PMID: 29025011
DOI: 10.1093/biolre/iox112

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