Article
Epidermal growth factor receptor signaling uncouples germ cells from the somatic follicular compartment at ovulation
4 Mar 2021
Abstract excerpt
Germ cells are physically coupled to somatic support cells of the gonad during differentiation, but this coupling must be disrupted when they are mature, freeing them to participate in fertilization. In mammalian females, coupling occurs via specialized filopodia that project from the ovarian follicular granulosa cells to the oocyte. Here, we show that signaling through the epidermal growth factor receptor (EGFR)...
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