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SP1 governs primordial folliculogenesis by regulating pregranulosa cell development in mice

25 Jun 2019

Abstract excerpt

Establishment of the primordial follicle (PF) pool is pivotal for the female reproductive lifespan; however, the mechanism of primordial folliculogenesis is poorly understood. Here, the transcription factor SP1 was shown to be essential for PF formation in mice. Our results showed that SP1 is present in both oocytes and somatic cells during PF formation in the ovary. Knockdown of Sp1 expression, especially in...

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PMID: 31282930
DOI: 10.1093/jmcb/mjz059

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