Article

RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2

2019-04-04

Abstract excerpt

Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian granulosa cells or testicular Sertoli cells. This process of fate specification hinges on a balance of transcriptional control. We discovered that expression of the transcription factor RUNX1 is enriched in the fetal ovary in rainbow trout, turtle, mouse, goat and human. In the mouse, RUNX1 marks the supp...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e5ad2115-cefe-5244-b4a7-9e668caa06be
DOI: 10.1101/598607

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

RUNX1 safeguards the identity of the fetal ovary through an interplay with FOXL2DOI 10.1101/598607Read

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2Semantic proximity Read

Genome-wide identification of FOXL2 binding and characterization of FOXL2 feminizing action in the fetal gonadsSemantic proximity Read

FOXL2 versus SOX9: A lifelong “battle of the sexes”Semantic proximity Read

Involvement of FOXL2 and RSPO1 in Ovarian Determination, Development, and Maintenance in MammalsSemantic proximity Read

From Sex Determination to Initial Folliculogenesis in Mammalian Ovaries: Morphogenetic Waves along the Anteroposterior and Dorsoventral AxesSemantic proximity Read

Insights Into the Roles of GATA Factors in Mammalian Testis Development and the Control of Fetal Testis Gene ExpressionSemantic proximity Read

Dissecting the fate of Foxl2-expressing cells in fetal ovary using lineage tracing and single-cell transcriptomicsSemantic proximity Read

WOMEN IN REPRODUCTIVE SCIENCE: To be or not to be a testisSemantic proximity Read

Minireview: transcriptional regulation of gonadal development and differentiation.Semantic proximity Read

Single-cell transcriptome landscape of developing fetal gonads defines somatic cell lineage specification in humansSemantic proximity Read

A spatiotemporal gene expression and cell atlases of the developing rat ovarySemantic proximity Read

Origin, specification and differentiation of a rare supporting-like lineage in the developing mouse gonadSemantic proximity Read