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Article

RUNX1 maintains the identity of the fetal ovary through an interplay with FOXL2

11 Nov 2019

Abstract excerpt

Sex determination of the gonads begins with fate specification of gonadal supporting cells into either ovarian pre-granulosa cells or testicular Sertoli cells. This fate specification hinges on a balance of transcriptional control. Here we report that expression of the transcription factor RUNX1 is enriched in the fetal ovary in rainbow trout, turtle, mouse, goat, and human. In the mouse, RUNX1 marks the...

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PMID: 31712577
DOI: 10.1038/s41467-019-13060-1

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