Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate.

The Journal of biological chemistry - 22 Nov 2002

Okuda Takashi, Okamura Michiko, Kaitsuka China, Haga Tatsuya, Gurwitz David

Abstract excerpt

High affinity choline uptake plays a critical role in the regulation of acetylcholine synthesis in cholinergic neurons. Recently, we succeeded in molecular cloning of the high affinity choline transporter (CHT1), which is specifically expressed in cholinergic neurons. Here we demonstrate the presence of functionally relevant, nonsynonymous single nucleotide polymorphism in the human CHT1 gene by comprehensive...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylcholine
Share to Chlorides
Share to Choline

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Membrane Transport Proteins

Share to Protein Structure, Secondary

Share to Sodium

Share to Spinal Cord

Source

Identifiers

PMID: 12237312
DOI: 10.1074/jbc.M207742200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single nucleotide polymorphism of the human high affinity choline transporter alters transport rate.PMID 12237312Read ↗

Biochemical characterization of two novel mutations in the human high-affinity choline transporter 1 identified in a patient with congenital myasthenic syndrome.Semantic proximity Read ↗

Transmembrane topology and oligomeric structure of the high-affinity choline transporter.Semantic proximity Read ↗

Choline transporter gene variation is associated with attention-deficit hyperactivity disorderSemantic proximity Read ↗

Disrupted choline clearance and sustained acetylcholine release <i>in vivo</i> by a common choline transporter coding variant associated with poor attentional control in humansSemantic proximity Read ↗

Choline transporter mutations in severe congenital myasthenic syndrome disrupt transporter localizationSemantic proximity Read ↗

Presynaptic congenital myasthenic syndrome due to three novel mutations in SLC5A7 encoding the sodium-dependant high-affinity choline transporter.Semantic proximity Read ↗

Choline Acetyltransferase Mutations Causing Congenital Myasthenic Syndrome: Molecular Findings and Genotype-Phenotype Correlations.Semantic proximity Read ↗

Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice.Semantic proximity Read ↗

Defective presynaptic choline transport underlies hereditary motor neuropathy.Semantic proximity Read ↗

Common genetic polymorphisms affect the human requirement for the nutrient choline.Semantic proximity Read ↗

Identification of new genetic polymorphisms that alter the dietary requirement for choline and vary in their distribution across ethnic and racial groups.Semantic proximity Read ↗

Structural insights into a conserved mechanism of choline translocation through CHTSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.