Back to search

Article

A Differential Ion Mobility Acoustic Ejection Mass Spectrometer System for Screening Isomerization-Mediating Enzyme Drug Targets

2024-09-27

Abstract excerpt

We report the first implementation of ion mobility mass spectrometry combined with an ultra-high throughput sample introduction technology for high throughput screening (HTS). The system integrates differential ion mobility (DMS) with acoustic ejection mass spectrometry (AEMS), termed DAEMS, enabling the simultaneous quantitation of structural isomers that are the sub-strates and products of isomerase mediated rea...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
b5ec5b87-511f-56a0-a65c-12cb9648c718
DOI
10.1101/2024.09.25.614780
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 8 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
A Differential Ion Mobility Acoustic Ejection Mass Spectrometer System for Screening Isomerization-Mediating Enzyme Drug TargetsDOI 10.1101/2024.09.25.614780
rtmsEcho: An Open-Source R Package for Automated Analysis of Acoustic Ejection Mass Spectrometry DataSemantic proximity
TIMS-Bench: Towards community standards for benchmarking untargeted trapped ion mobility metabolomics tools and datasetsSemantic proximity
Multi-capillary Column Ion Mobility Spectrometry of Volatile Metabolites for Phenotyping of Microorganisms.Semantic proximity
High-throughput, accurate mass metabolome profiling of cellular extracts by flow injection-time-of-flight mass spectrometry.Semantic proximity
Structural mass spectrometry analysis of lipid changes in a Drosophila epilepsy model brain.Semantic proximity
Ion Mobility–Enhanced Liquid Chromatography Coupled with Mass Spectrometry (LC–MS) Enables Reliable Detection of OXA-48-Like Carbapenemases Beyond Conventional Activity-Based AssaysSemantic proximity
Electron capture dissociation and drift tube ion mobility-mass spectrometry coupled with site directed mutations provide insights into the conformational diversity of a metamorphic protein.Semantic proximity
A targeted metabolomic method to detect epigenetically relevant metabolitesSemantic proximity
Select a neighboring publication to make it the new centre.