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Article

Targeted Mass Spectrometry Analyses of Somatic Mutations in Colorectal Cancer Specimens Using Differential Ion Mobility.

Journal of proteome research - 2 Feb 2024

Wu Zhaoguan, Bonneil Éric, Belford Michael, Boeser Cornelia, Dunyach Jean-Jacques, Thibault Pierre

Abstract excerpt

Identification of K-Ras and B-Raf mutations in colorectal cancer (CRC) is essential to predict patients' response to anti-EGFR therapy and formulate appropriate therapeutic strategies to improve prognosis and survival. Here, we combined parallel reaction monitoring (PRM) with high-field asymmetric waveform ion mobility (FAIMS) to enhance mass spectrometry sensitivity and improve the identification of...

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Identifiers

PMID: 38153093
DOI: 10.1021/acs.jproteome.3c00444

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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