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Article

Development of an in situ CAR-T cell protocol through optical and PSMA-targeted PET imaging

10 Jun 2025

Abstract excerpt

In situ T cell transfection methods overcome the complexity and high costs associated with conventional chimeric antigen receptor (CAR)-T therapy. However, the in situ CAR-T cell approach operates within the patient’s complex immune environment and bypasses preinfusion ex vivo cellular quality controls, necessitating advanced imaging techniques to track immune cell migration and function. Positron emission...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 40493195
DOI: 10.1073/pnas.2504950122

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