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Article

Claudin-4 activity in ovarian tumor cell apoptosis resistance and migration

11 Oct 2016

Abstract excerpt

BACKGROUND: Claudin-4 is a transmembrane protein expressed at high levels in the majority of epithelial ovarian tumors, irrespective of subtype, and has been associated with tumor cells that are both chemoresistant and highly mobile. The objective of this study was to determine the functional role that claudin-4 plays in apoptosis resistance and migration as well as the therapeutic utility of targeting claudin-4...

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PMID: 27724921
DOI: 10.1186/s12885-016-2799-7

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