Article

A zebrafish model of nicotinamide adenine dinucleotide (NAD <sup>+</sup> ) deficiency-derived congenital disorders

2025-01-10

Abstract excerpt

Congenital NAD deficiency disorder (CNDD) is a multisystem condition in which cardiac, renal, vertebral, and limb anomalies are most common, but anomalies in all organ systems have been identified. Patients with this condition have biallelic pathogenic variants involving genes in the nicotinamide adenine dinucleotide (NAD + ) synthesis pathway leading to decreased systemic NAD + levels. CNDD anomalies mimic the...

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Literature Corpus work: 5b9dcdeb-09be-552d-887e-5a0f5f3ba7d8
DOI: 10.1101/2025.01.10.632366

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