Article

Reprogramming of endogenous Müller cells into photoreceptor-like cells induced by small-molecule compounds in mice

2021-09-17

Abstract excerpt

Lifelong visual impairment occurs from retinal diseases due to the inability of photoreceptor cells to regenerate in mammals. We demonstrated that endogenous Müller cells (MCs) in mice differentiate into photoreceptor-like cells by intravitreal injection of four small-molecule compounds: tumor growth factor-β inhibitor, bone morphogenetic protein inhibitor, glycogen synthase kinase 3 inhibitor, and γ-secretase inh...

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Literature Corpus work: e4b1bb8a-b32f-5fde-979b-8aa3ce86c0d2
DOI: 10.21203/rs.3.rs-890527/v1

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