Article
The acquisition order of leukemic drug resistance mutations is directed by the selective fitness associated with each resistance mechanism.
Scientific reports - 11 Aug 2023
Leow Benjamin C S, Kok Chung H, Yeung David T, Hughes Timothy P, White Deborah L, Eadie Laura N
Abstract excerpt
In Chronic Myeloid Leukemia, the transition from drug sensitive to drug resistant disease is poorly understood. Here, we used exploratory sequencing of gene transcripts to determine the mechanisms of drug resistance in a dasatinib resistant cell line model. Importantly, cell samples were collected sequentially during drug exposure and dose escalation, revealing several resistance mechanisms which fluctuated over...
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