Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug resistance: still a daunting challenge to the successful treatment of AML.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Jan 2000

Shaffer Brian C, Gillet Jean-Pierre, Patel Chirayu, Baer Maria R, Bates Susan E, Gottesman Michael M

Abstract excerpt

Resistance to chemotherapy remains a challenging issue for patients and their physicians. P-glycoprotein (Pgp, MDR1, ABCB1), as well as a family of structurally and functionally related proteins, are plasma membrane transporters able to efflux a variety of substrates from the cell cytoplasm, incl...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ATP Binding Cassette Transporter, Subfamily B
Share to ATP Binding Cassette Transporter, Subfamily B, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Transport

Share to Clinical Trials as Topic

Share to Epigenesis, Genetic

Share to Leukemia, Myeloid, Acute

Share to Neoplastic Stem Cells

Share to Protein Isoforms

Source

Open in PubMed Open full text

Identifiers

PMID: 22409994
DOI: 10.1016/j.drup.2012.02.001
PMCID: PMC3348380

Genes

ABCB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22409994-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug resistance: still a daunting challenge to the successful treatment of AML.PMID 22409994Read ↗

Classical multidrug resistance in acute myeloid leukaemia.Semantic proximity Read ↗

Drug resistance mechanisms in acute leukemia.Semantic proximity Read ↗

Mechanisms of drug resistance in AML.Semantic proximity Read ↗

The Emergence of Drug Transporter-Mediated Multidrug Resistance to Cancer ChemotherapySemantic proximity Read ↗

Towards Comprehension of the ABCB1/P-Glycoprotein Role in Chronic Myeloid Leukemia.Semantic proximity Read ↗

How to overcome ATP-binding cassette drug efflux transporter-mediated drug resistance?Semantic proximity Read ↗

ABCA1 is associated with the development of acquired chemotherapy resistance and predicts poor ovarian cancer outcomeSemantic proximity Read ↗

Targeting the multidrug resistance-1 transporter in AML: molecular regulation and therapeutic strategiesSemantic proximity Read ↗

The controversial role of ABC transporters in clinical oncologySemantic proximity Read ↗

ABC Transporter Inhibitors in Reversing Multidrug Resistance to ChemotherapySemantic proximity Read ↗

What “The Cancer Genome Atlas” database tells us about the role of ATP-binding cassette (ABC) proteins in chemoresistance to anticancer drugsSemantic proximity Read ↗

Mechanisms of drug resistance in acute myeloid leukemiaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.