Article

Stattic Attenuates LPS- and CIRBP-Induced Inflammatory Signaling in THP-1 Macrophages

2026-05-13

Abstract excerpt

Extracellular cold-inducible RNA-binding protein (eCIRBP) is a key driver of sterile inflammation following ischemia/reperfusion (I/R) injury, such as during cardiac surgery. While eCIRBP’s interaction with the TLR4/MD2 complex is known to activate the NF-κB pathway, its role in activating the JAK/STAT3 pathway via the IL-6 receptor (IL-6R) is less understood. To investigate this, human THP-1-derived macrophage-li...

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Literature Corpus work: e456a327-ecdc-5477-a0bc-96543942cdc8
DOI: 10.20944/preprints202605.0852.v1

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