A Retinoic Acid Autoregulatory Loop Governing Prefrontal-Motor Arealization

Abstract excerpt

The frontal lobe comprises the prefrontal association cortex (PFC), which supports complex cognition and goal-directed behavior, and the motor cortex (MC), which executes movement. A hallmark of primate brain evolution is PFC expansion accompanied by a posterior displacement of the MC. Retinoic acid (RA) signaling has emerged as a key regulator of PFC specification and expansion. However, the mechanisms that spati...

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Identifiers and source

Literature Corpus work

e3feb6ce-c469-5826-907e-f940cba7e34b

DOI

10.64898/2025.12.23.696038