Article

A Large Animal Model of Heritable Pulmonary Arterial Hypertension Using Gene-edited <i>BMPR2</i> Sheep

2026-02-07

Abstract excerpt

Pulmonary Arterial Hypertension (PAH) is a rare vascular disorder characterized by elevated pressure in pulmonary arteries, eventually leading to right ventricular failure. Approximately 50% of pediatric disease and 20% of adult disease can be linked to a genetic mutation, with nearly 70% of these cases involving mutations in the bone morphogenetic protein receptor type 2 ( BMPR2 ) locus. Investigations using rod...

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Literature Corpus work: e3fa3c8d-d029-5557-951e-48d743901e45
DOI: 10.64898/2026.02.06.704456

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