Article
Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension.
Respiratory research - 1 Jan 2001
De Caestecker M, Meyrick B
Abstract excerpt
Several recent papers have shown that both familial primary pulmonary hypertension (FPPH) and sporadic primary pulmonary hypertension (PPH) may have a common etiology that is associated with the inheritance and/or spontaneous development of germline mutations in the bone morphogenetic protein receptor (BMPR) type II gene. Because BMPR-II is a ubiquitously expressed receptor for a family of secreted growth factors...
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