Article

Real-Time Confocal Imaging for Evaluation of Dose-Dependent Effects of Gamma Knife Radiosurgery on Glioblastoma Cell Lines

2026-05-29

Abstract excerpt

<title>Abstract</title> <p>Purpose: To characterize, in real time, how single-fraction low-dose Gamma Knife stereotactic radiosurgery (GKRS) affects proliferation and cell-cycle dynamics in glioblastoma (GBM) cells across a range of doses. We hypothesized that a 2.5 Gy dose would induce mitotic failure and cell death, whereas low doses (< 1 Gy) might elicit adaptive or hormetic responses. METHODS: Human U-87 MG...

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Literature Corpus work: e3dcc4d0-a04e-5405-b325-e2234e55e682
DOI: 10.21203/rs.3.rs-9777079/v1

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