Article

ALS and FTD-associated missense mutations in TBK1 differentially disrupt mitophagy

2021-04-12

Abstract excerpt

<h4>ABSTRACT</h4> TANK-binding kinase 1 (TBK1) is a multi-functional kinase with an essential role in mitophagy, the selective clearance of damaged mitochondria. More than 90 distinct mutations in TBK1 are linked to amyotrophic lateral sclerosis (ALS) and fronto-temporal dementia (FTD), including missense mutations that disrupt the ability of TBK1 to dimerize, associate with the mitophagy receptor optineurin (OPT...

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Literature Corpus work: e3ab8b1e-bdef-5da8-bc69-5e6d3c522de0
DOI: 10.1101/2021.04.12.439050

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