Article

TDP-43 subcellular mislocalisation is correlated with loss of optineurin binding for frontotemporal dementia and amyotrophic lateral sclerosis associated <i>TBK1</i> missense variants

2022-06-03

Abstract excerpt

<h4>Background</h4> Frontotemporal dementia (FTD) is one of the most common forms of younger-onset dementia. FTD is genetically, pathologically and clinically related to amyotrophic lateral sclerosis (ALS), a rapidly progressive neurodegenerative disorder. Mutations in TANK-binding kinase 1 ( TBK1 ) have been identified as a rare cause of FTD and ALS. TBK1 has known roles in inflammation and autophagy and intera...

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Literature Corpus work: 8054b29e-af46-55a7-b799-f42357f45819
DOI: 10.1101/2022.06.02.494603

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